Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults
Identifieur interne : 002B16 ( Main/Exploration ); précédent : 002B15; suivant : 002B17Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults
Auteurs : Douglas D. Richman [États-Unis] ; Brian R. Murphy [États-Unis] ; Robert M. Chanock [États-Unis] ; Jack M. Gwaltney [États-Unis] ; R. Gordon Douglas [États-Unis] ; Douglas Betts [États-Unis] ; Neil R. Blacklow [États-Unis] ; Frederick B. Rose [États-Unis] ; Thomas A. Parrino [États-Unis] ; Myron M. Levine [États-Unis] ; Ellis S. Caplan [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1976.
Abstract
The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.
Url:
DOI: 10.1093/infdis/134.6.585
Affiliations:
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Gordon Douglas</name></author><author><name sortKey="Betts, Douglas" sort="Betts, Douglas" uniqKey="Betts D" first="Douglas" last="Betts">Douglas Betts</name></author><author><name sortKey="Blacklow, Neil R" sort="Blacklow, Neil R" uniqKey="Blacklow N" first="Neil R." last="Blacklow">Neil R. Blacklow</name></author><author><name sortKey="Rose, Frederick B" sort="Rose, Frederick B" uniqKey="Rose F" first="Frederick B." last="Rose">Frederick B. Rose</name></author><author><name sortKey="Parrino, Thomas A" sort="Parrino, Thomas A" uniqKey="Parrino T" first="Thomas A." last="Parrino">Thomas A. Parrino</name></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name></author><author><name sortKey="Caplan, Ellis S" sort="Caplan, Ellis S" uniqKey="Caplan E" first="Ellis S." last="Caplan">Ellis S. 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XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-<hi rend="italic">ts</hi>-l[E] Recombinant Viruses in Human Adults</title><author><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Gwaltney, Jack M" sort="Gwaltney, Jack M" uniqKey="Gwaltney J" first="Jack M." last="Gwaltney">Jack M. Gwaltney</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Douglas, R Gordon" sort="Douglas, R Gordon" uniqKey="Douglas R" first="R. Gordon" last="Douglas">R. Gordon Douglas</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Betts, Douglas" sort="Betts, Douglas" uniqKey="Betts D" first="Douglas" last="Betts">Douglas Betts</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Blacklow, Neil R" sort="Blacklow, Neil R" uniqKey="Blacklow N" first="Neil R." last="Blacklow">Neil R. Blacklow</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="Rose, Frederick B" sort="Rose, Frederick B" uniqKey="Rose F" first="Frederick B." last="Rose">Frederick B. Rose</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Parrino, Thomas A" sort="Parrino, Thomas A" uniqKey="Parrino T" first="Thomas A." last="Parrino">Thomas A. Parrino</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Caplan, Ellis S" sort="Caplan, Ellis S" uniqKey="Caplan E" first="Ellis S." last="Caplan">Ellis S. Caplan</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1976-12">1976</date><biblScope unit="vol">134</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="577">577</biblScope><biblScope unit="page" to="554">554</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name></region><name sortKey="Betts, Douglas" sort="Betts, Douglas" uniqKey="Betts D" first="Douglas" last="Betts">Douglas Betts</name><name sortKey="Blacklow, Neil R" sort="Blacklow, Neil R" uniqKey="Blacklow N" first="Neil R." last="Blacklow">Neil R. Blacklow</name><name sortKey="Caplan, Ellis S" sort="Caplan, Ellis S" uniqKey="Caplan E" first="Ellis S." last="Caplan">Ellis S. Caplan</name><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><name sortKey="Douglas, R Gordon" sort="Douglas, R Gordon" uniqKey="Douglas R" first="R. Gordon" last="Douglas">R. Gordon Douglas</name><name sortKey="Gwaltney, Jack M" sort="Gwaltney, Jack M" uniqKey="Gwaltney J" first="Jack M." last="Gwaltney">Jack M. Gwaltney</name><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><name sortKey="Parrino, Thomas A" sort="Parrino, Thomas A" uniqKey="Parrino T" first="Thomas A." last="Parrino">Thomas A. Parrino</name><name sortKey="Rose, Frederick B" sort="Rose, Frederick B" uniqKey="Rose F" first="Frederick B." last="Rose">Frederick B. Rose</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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